Coupling toxicokinetics and pharmacodynamics for predicting survival of abalone (Haliotis diversicolor supertexta) exposed to waterborne zinc

doi:10.1002/tox.10082

NHUIR > Center for General Education > Periodical Articles > Item 987654321/26137

Please use this identifier to cite or link to this item: http://nhuir.nhu.edu.tw/handle/987654321/26137

Title:	Coupling toxicokinetics and pharmacodynamics for predicting survival of abalone (Haliotis diversicolor supertexta) exposed to waterborne zinc
Authors:	林明炤;Lin, Ming-Chao;Liao, Chung-Min;Chen, Bo-Ching;Chiu, Hsiao-Mei;Chou, Yun-Hua
Contributors:	通識教育中心
Keywords:	abalone;mortality;pharmacodynamics;toxicity;toxicokinetics;zinc
Date:	2002-09
Issue Date:	2018-06-13 10:08:32 (UTC+8)
Abstract:	We developed a mortality model, by coupling an acute toxicity model and a pharmacodynamic model, to predict survival of abalone (Haliotis diversicolor supertexta) exposed to waterborne zinc (Zn). We conducted a laboratory 14-day exposure experiment to obtain biokinetic parameters of depuration rate constant (k₂) and bioconcentration factor (BCF). A one-compartment uptake–depuration model was used to fit the exposure data to estimate BCF and k₂ values. The acute toxicity model was developed based on the receptor theory and was verified with LC₅₀(t) data obtained from a 7-day acute toxicity test. A highly significant correlation (r² = 0.98) was found between predictions and LC₅₀(t) data for the acute toxicity model, indicating a successful description of 7-day LC50(t) data of Zn in abalone. The predicted time course of lethal body burden of Zn in abalone was compared with measured data, showing that the average percent error was 14.04 ± 3.02%. A refined pharmacodynamic model was expressed as the Hill equation, which in terms of waterborne Zn and LC₅₀(t) data was used to fit observed mortality percentages to determine the Hill coefficient (r² = 0.98). The proposed mortality model in terms of whole body burden and lethal body burden at site of action was then employed to predict the time-varying mortality of abalone exposed to various Zn concentrations in pond water. Our results demonstrate that 96-h LC₅₀ and incipient LC₅₀ for H. diversicolor supertexta exposed to Zn are 1.1 and 1.05 mg L⁻¹, respectively. Our predictions also demonstrate that equilibrium lethal body burden at site of action is about 198 μg g⁻¹, whereas the mortalities never reach 50% when H. diversicolor supertexta exposed to Zn is ⩽ 1 mg L⁻¹.
Relation:	Environmental Toxicology vol. 17, no. 5 pp.478-486
Appears in Collections:	[Center for General Education] Periodical Articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	630	View/Open

Loading...